Description: Azithromycin hydrochloride for injection contains the active ingredient azithromycin, an azalide, a subclass of macrolide antibiotics, for intravenous injection. Azithromycin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13- [(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-hepta-methyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azithromycin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl- substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Pharmacological effects: Azithromycin is a member of macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they: interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Azithromycin is active against both gram positive and gram negative aerobic and anaerobic bacteria
Pharmacokinetics: Absorption: Azithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is not metabolized in the body. Excretion: It is primarily excreted through bile and a very small amount excreted through urine.

Indications: This applies to sensitive goods caused by the bacteria of the following infections: Otitis media, sinusitis, pharyngitis and tonsillitis, upper respiratory infection; Bronchitis, pneumonia and other lower respiratory tract infections. Skin and soft tissue infections. Genital Chlamydia trachomatis infections caused by simple. 

Adverse reaction: Adverse reactions that occurred with a frequency of 1% or less included the following: Gastrointestinal: dyspepsia, flatulence, mucositis, oral moniliasis, and gastritis. Nervous System: headache, somnolence. Allergic: bronchospasm. Special Senses: taste perversion.